Endocrine Abstracts

The adipose tissue is an endocrine organ distributed over multiple depots and broadly categorised into two main subtypes: white adipose tissue which stores energy as lipids and brown adipose tissue which dissipates energy in the form of heat. Adipocytes from the white depots are able to switch from a white to a brown-like phenotype, a process called beiging. This phenomenon is stimulated by cold exposure or sympathetic nervous system activation and is associated with improved ...

The adrenal gland produces corticosteroids essential for hydromineral and metabolic homeostasis. It is organised, in mice, in two concentric layers. The zona glomerulosa (zG) and fasciculate (zF), renewed from progenitors located in the capsular periphery. Centripetal renewal and maintenance of cortical zonation are dependant of a balance between WNT/β-catenin and ACTH/PKA signalling pathways. They provide recruitment and consecutive differentiation of progenitors into zG...